ABSTRACT
The distribution and conformational changes of the fibers of the collagenous and elastic systems in guinea pig airways after a contractile agonist challenge are described. We observed a distinct pattern of behavior within the mucosal fibers during bronchoconstriction. Part of the fibers of the two systems tend to follow the epithelial invaginations towards the airway lumen, while the remaining ones seem to be attached to the internal smooth muscle. These layers of fibers in the mucosa are interconnected to one another and to the adventitial network by slender fibers. We suggest that the configuration and behavior of these fibers during bronchoconstriction may contribute to airway reopening after the contractile stimulus has ceased. The possible role of this mechanism in the pathophysiology of human asthma is discussed.
Subject(s)
Guinea Pigs , Animals , Bronchoconstriction/physiology , Collagen/physiology , Elastic Tissue/physiology , Elastin/metabolism , Asthma/physiopathology , Bronchi/ultrastructureABSTRACT
Los autores analizan los problemas del tratamiento quirúrgico de las neuritis hansenianas. Se establecen los criterios que deben ser utilizados. Ubican la cirugía en el contexto terapéutico. Presentan ejemplos de su casuística. Se sugiere uniformar los criterios a fin de tornar comparativos los resultados